Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.53 |
| ▸ | PNLIP | P16233 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9440384 | 0.89 | MAPT (0.57) | MAPTPDE7APNLIPALDH1A1KDM4E | |
| SCHEMBL4318630 | 0.89 | PDE7A (0.63) | MAPTPDE7APNLIPALDH1A1KDM4E | |
| SCHEMBL10962941 | 0.87 | MAPT (0.55) | MAPTPDE7APNLIPALDH1A1KDM4E | |
| SCHEMBL29553590 | 0.85 | MAOA (0.61) | MAPTPDE7APNLIPALDH1A1KDM4E | |
| SCHEMBL554722 | 0.85 | MAOA (0.61) | MAPTPDE7APNLIPALDH1A1KDM4E | |
| SCHEMBL1147436 | 0.82 | PDE7A (0.53) | MAPTPDE7APNLIPALDH1A1KDM4E | |
| SCHEMBL5583563 | 0.82 | TEAD4 (0.57) | MAPTPDE7APNLIPALDH1A1KDM4E | |
| SCHEMBL10703684 | 0.82 | PDE7A (0.53) | MAPTPDE7APNLIPALDH1A1KDM4E | |
| SCHEMBL30617019 | 0.81 | CYP3A4 (0.58) | MAPTPDE7APNLIPALDH1A1MEN1 | |
| SCHEMBL1374919 | 0.81 | CYP3A4 (0.58) | MAPTPDE7APNLIPALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |