Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22069698 | 0.89 | MAPT (0.57) | MAPTPDE7AMAOAMAOBALDH1A1 | |
| SCHEMBL9272342 | 0.85 | MAPT (0.50) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4318630 | 0.85 | PDE7A (0.63) | MAPTPDE7AMAOAMAOBALDH1A1 | |
| SCHEMBL10962941 | 0.83 | MAPT (0.55) | MAPTPDE7AALDH1A1CYP3A4TSHR | |
| SCHEMBL8683893 | 0.82 | STK39 (0.46) | MAPTTSHRMEN1KMT2AHPGD | |
| SCHEMBL9440387 | 0.82 | SCN9A (0.44) | PDE7AALDH1A1TDP1HTR2ASLC6A4 | |
| SCHEMBL11606863 | 0.82 | MAPT (0.47) | MAPTALDH1A1TSHRTDP1MEN1 | |
| SCHEMBL8683891 | 0.82 | KMT2A (0.43) | MAPTPDE7AALDH1A1TSHRTDP1 | |
| SCHEMBL1129611 | 0.81 | SLC6A4 (0.50) | MAPTALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL554810 | 0.81 | MAOA (0.61) | MAPTPDE7AMAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276037-A | Antiinflammatory agents, antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-04 | — | — | US | disclosed |
| US-5272173-A | 5-lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-21 | — | — | US | disclosed |
| US-5225438-A | Lipoxygenase inhibitors for antiinflammatory agents or antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-07-06 | — | — | US | disclosed |
| EP-0488602-A1 | Aryl derivatives | ZENECA LIMITED (GB) | 1992-06-03 | — | — | EP | disclosed |
| US-4355186-A | Process for the preparation of 4-phenoxy-phenols | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-10-19 | — | — | US | disclosed |