Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.50 |
| ▸ | MAOB | P27338 | 7/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6297991 | 0.93 | MAPK1 (0.46) | MAPK1TSHRKDM4EMTNR1AMTNR1B | |
| SCHEMBL1602223 | 0.83 | TSHR (0.47) | MAPK1TSHRALDH1A1TDP1L3MBTL1 | |
| SCHEMBL22069660 | 0.83 | ADRB2 (0.50) | TDP1L3MBTL1 | |
| SCHEMBL1951190 | 0.82 | CYP2C9 (0.50) | MAPK1TSHRKDM4EALDH1A1 | |
| SCHEMBL29421566 | 0.81 | MAOB (0.49) | KDM4EMAOBTP53ALDH1A1L3MBTL1 | |
| SCHEMBL14431806 | 0.81 | USP2 (0.45) | MAOBTP53 | |
| SCHEMBL11634063 | 0.81 | KMT2A (0.48) | MAPK1KDM4ELMNA | |
| SCHEMBL102555 | 0.81 | MAOB (0.49) | KDM4EMAOBTP53ALDH1A1L3MBTL1 | |
| SCHEMBL1193076 | 0.80 | LMNA (0.53) | MTNR1AMTNR1BTDP1LMNA | |
| SCHEMBL12021780 | 0.79 | TSHR (0.44) | MAPK1TSHRMTNR1AMTNR1BMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |