Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | P2RX4 | Q99571 | 11/20 | 0.57 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.54 |
| ▸ | STK39 | Q9UEW8 | 2/20 | 0.53 |
| ▸ | RNF4 | P78317 | 1/20 | 0.51 |
| ▸ | PNLIP | P16233 | 2/20 | 0.51 |
| ▸ | PARG | Q86W56 | 2/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22069611 | 0.88 | P2RX4 (0.57) | MITFALDH1A1POLBMAPK1HTT | |
| SCHEMBL22069659 | 0.86 | P2RX4 (0.54) | ALDH1A1P2RX4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL22069619 | 0.85 | PNLIP (0.64) | HTTSTK39PNLIP | |
| SCHEMBL31536382 | 0.85 | PNLIP (0.64) | HTTSTK39PNLIP | |
| SCHEMBL31703396 | 0.84 | RNF4 (0.73) | MITFALDH1A1POLBMAPK1HTT | |
| SCHEMBL22069549 | 0.82 | ESRRA (0.54) | ALDH1A1POLBSTK39PNLIP | |
| SCHEMBL22069618 | 0.81 | ESRRA (0.53) | MITFALDH1A1POLBMAPK1HTT | |
| SCHEMBL22069753 | 0.81 | PNLIP (0.54) | MITFALDH1A1POLBMAPK1HTT | |
| SCHEMBL22069693 | 0.79 | ESRRA (0.51) | POLBSTK39RNF4PNLIPPARG | |
| SCHEMBL2529601 | 0.78 | GRM4 (0.67) | STK39PNLIPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |