SCHEMBL22070515

SCHEMBL22070515

CCOC(=O)Cc1cccc(COc2ccc(-c3cnn(C4CCCCO4)c3)nc2)c1

nearest known ligand 0.51

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 16/20 0.51
CYP4A11 Q02928 16/20 0.51
MAOB P27338 2/20 0.40
FGFR1 P11362 1/20 0.39
FGFR2 P21802 1/20 0.39
FGFR4 P22455 1/20 0.39
FGFR3 P22607 1/20 0.39
KDR P35968 1/20 0.39
FLT3 P36888 1/20 0.39
MCL1 Q07820 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20590902 0.82 CYP4F2 (0.54) CYP4F2CYP4A11FGFR1FGFR2FGFR4
SCHEMBL22071074 0.78 CYP4F2 (0.73) CYP4F2CYP4A11
SCHEMBL22070918 0.73 CYP4F2 (0.66) CYP4F2CYP4A11
SCHEMBL29642031 0.73 CYP4F2 (0.66) CYP4F2CYP4A11
SCHEMBL20590800 0.73 CYP4F2 (0.80) CYP4F2CYP4A11
SCHEMBL20590874 0.73 CYP4F2 (0.53) CYP4F2CYP4A11FGFR1FGFR2FGFR4
SCHEMBL23272081 0.73 CYP4F2 (0.62) CYP4F2CYP4A11
SCHEMBL20590888 0.71 CYP4F2 (0.80) CYP4F2CYP4A11MAOB
SCHEMBL19277419 0.71 CYP4F2 (0.43) CYP4F2CYP4A11FGFR1FGFR2FGFR4
SCHEMBL13739332 0.71 RXRA (0.54) CYP4F2CYP4A11FGFR1FGFR2FGFR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11365192-B2 Pyridine compound substituted with azole TAISHO PHARMACEUTICAL CO., LTD. (JP) 2022-06-21 US disclosed
US-20210122741-A1 PYRIDINE COMPOUND SUBSTITUTED WITH AZOLE TAISHO PHARMACEUTICAL CO., LTD (JP) 2021-04-29 US disclosed
EP-3666766-A1 PYRIDINE COMPOUND SUBSTITUTED WITH AZOLE Taisho Pharmaceutical Co., Ltd. (JP) 2020-06-17 EP disclosed
CN-110914254-A Azole-substituted pyridine compound 大正制药株式会社 2020-03-24 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210122741-A1 PYRIDINE COMPOUND SUBSTITUTED WITH AZOLE CYP2C19, CYP4A11, CYP11B1 CYP4F2 20/4885CYP4A11 2/4885MAOB 230/4885
US-11365192-B2 Pyridine compound substituted with azole CYP2C19, CYP4A11, CYP11B1 CYP4F2 20/4885CYP4A11 2/4885MAOB 230/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.