Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 10/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22078073 | 0.85 | ADH5 (0.44) | TBXAS1CYP3A4ALDH1A1HTT | |
| SCHEMBL22077999 | 0.84 | DYRK1A (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22078074 | 0.83 | TBXAS1 (0.47) | TBXAS1 | |
| SCHEMBL22078070 | 0.81 | TBXAS1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22077254 | 0.81 | ESR1 (0.41) | LMNATBXAS1CYP3A4CYP2D6 | |
| SCHEMBL22077044 | 0.81 | TBXAS1 (0.47) | TBXAS1 | |
| SCHEMBL22078079 | 0.80 | ADH5 (0.40) | TBXAS1 | |
| SCHEMBL22077994 | 0.79 | ADH5 (0.38) | TBXAS1 | |
| SCHEMBL22077004 | 0.77 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22078003 | 0.77 | TBXAS1 (0.47) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609867-B1 | CARBAZOLE COMPOUNDS AND METHODS OF USE THEREOF | GSNO THERAPEUTICS INC (US) | 2024-05-15 | — | — | EP | disclosed |
| US-11655244-B2 | Carbazole compounds and methods of use thereof | GSNO THERAPEUTICS, INC. (US) | 2023-05-23 | — | — | US | disclosed |
| US-11655244-B2 | Carbazole compounds and methods of use thereof | GSNO THERAPEUTICS, INC. (US) | 2023-05-23 | — | — | US | disclosed |
| US-20200181129-A1 | CARBAZOLE COMPOUNDS AND METHODS OF USE THEREOF | GSNO THERAPEUTICS, INC. | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11655244-B2 | Carbazole compounds and methods of use thereof | GSR, CBR3, CBR1 | PSEN1 3835/4885PSEN2 3536/4885APH1B 2378/4885 |
| US-20200181129-A1 | CARBAZOLE COMPOUNDS AND METHODS OF USE THEREOF | GSR, CBR3, CBR1 | PSEN1 3835/4885PSEN2 3536/4885APH1B 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.