Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 20/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827166 | 0.85 | ADRB2 (0.63) | ADRB2ADRB1ADRA1DDRD2 | |
| Bromide SCHEMBL1825951 | 0.84 | ADRB2 (0.62) | ADRB2ADRB1ADRA1DDRD2 | |
| SCHEMBL1827610 | 0.84 | ADRB2 (0.66) | ADRB2ADRB1ADRA1DDRD2 | |
| SCHEMBL435245 | 0.78 | ADRB2 (0.56) | ADRB2ADRB1ADRA1DDRD2DRD3 | |
| Trifluoroacetic Acid SCHEMBL2212361 | 0.78 | ADRB2 (0.64) | ADRB2 | |
| Trifluoroacetic Acid SCHEMBL2816554 | 0.78 | ADRB2 (0.56) | ADRB2 | |
| Trifluoroacetic Acid SCHEMBL2211871 | 0.78 | ADRB2 (0.58) | ADRB2 | |
| SCHEMBL4443114 | 0.75 | ADRB2 (0.68) | ADRB2 | |
| SCHEMBL2211014 | 0.75 | ADRB2 (0.65) | ADRB2ADRB1DRD2 | |
| SCHEMBL2214870 | 0.75 | ADRB2 (0.53) | ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121642-B1 | 4-HYDR0XY-2-0X0-2, 3 -DIHYDRO- 1, 3-BENZOTHIAZOL- 7YL COMPOUNDS FOR MODULATION OF B2-ADRENORECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2011-07-27 | — | — | EP | disclosed |