SCHEMBL22085490

SCHEMBL22085490

Cc1nn(C)c(=O)c(-c2c(F)ccc(Cl)c2CCc2ccccc2C(F)(F)F)c1O

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.38
THRB P10828 1/20 0.38
HSD17B13 Q7Z5P4 5/20 0.38
NR3C1 P04150 1/20 0.36
DPP4 P27487 1/20 0.35
DPP8 Q6V1X1 1/20 0.35
C5AR1 P21730 1/20 0.34
NPBWR1 P48145 1/20 0.34
LMNA P02545 1/20 0.34
LIPG Q9Y5X9 1/20 0.33
CNR1 P21554 1/20 0.33
KMT2A Q03164 1/20 0.33
HSP90AA1 P07900 1/20 0.33
HSP90B1 P14625 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22031792 0.84 CASR (0.40) MAPTLMNAKMT2A
SCHEMBL28800372 0.84 LMNA (0.35) MAPTTHRBNPBWR1LMNAKMT2A
SCHEMBL22084637 0.83 POLB (0.35) MAPTNR3C1DPP8NPBWR1LMNA
SCHEMBL29263844 0.81 HTR2A (0.39) MAPTLMNAKMT2A
SCHEMBL22084636 0.81 LMNA (0.36) MAPTNR3C1LMNAKMT2A
SCHEMBL22906297 0.81 LMNA (0.40) MAPTLMNAKMT2A
SCHEMBL22031854 0.80 CYP1A2 (0.38) MAPTLMNALIPG
SCHEMBL22031808 0.80 CNR1 (0.39) MAPTHSD17B13NR3C1CNR1
SCHEMBL29582055 0.80 CNR1 (0.39) MAPTHSD17B13NR3C1CNR1
SCHEMBL22085782 0.79 MAPT (0.37) MAPTLMNALIPGKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12162840-B2 Herbicidal compositions SYNGENTA CROP PROTECTION AG (CH) 2024-12-10 US claimed
EP-3890487-B1 HERBICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2024-06-12 EP claimed
US-20230301300-A1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2023-09-28 US claimed
US-20220119353-A1 Herbicidal Compositions SYNGENTA PARTICIPATIONS AG (CH) 2022-04-21 US claimed
US-20250304990-A1 HERBICIDE RESISTANCE SYNGENTA CROP PROTECTION AG (CH) 2025-10-02 US disclosed
CN-118265781-A Herbicide resistance 先正达农作物保护股份公司 2024-06-28 CN disclosed
US-20230301300-A1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2023-09-28 US disclosed
US-20230301300-A1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2023-09-28 US disclosed
WO-2023083972-A1 HERBICIDE RESISTANCE SYNGENTA CROP PROTECTION AG (CH) 2023-05-19 WO disclosed
US-20220119353-A1 Herbicidal Compositions SYNGENTA PARTICIPATIONS AG (CH) 2022-04-21 US disclosed
WO-2022033893-A1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2022-02-17 WO disclosed
WO-2020114869-A1 HERBICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2020-06-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12162840-B2 Herbicidal compositions DDT, HPD, PNPO MAPT 3247/4885THRB 2707/4885HSD17B13 894/4885
US-20230301300-A1 HERBICIDAL COMPOSITIONS GMDS, DDT, AADAC MAPT 3446/4885THRB 2912/4885HSD17B13 1392/4885
US-20220119353-A1 Herbicidal Compositions DDT, HPD, PNPO MAPT 3247/4885THRB 2707/4885HSD17B13 894/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.