Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30556292 | 1.00 | EGFR (0.54) | EGFRBRD4SLC2A1IGF1RKCNH2 | |
| SCHEMBL30556289 | 0.87 | EGFR (0.70) | EGFRIGF1RCDK2CDK1CCNE1 | |
| SCHEMBL22104361 | 0.87 | EGFR (0.70) | EGFRIGF1RCDK2CDK1CCNE1 | |
| SCHEMBL22104432 | 0.86 | EGFR (0.62) | EGFRIGF1RCDK2CDK1CCNE1 | |
| SCHEMBL30556290 | 0.86 | EGFR (0.62) | EGFRIGF1RCDK2CDK1CCNE1 | |
| SCHEMBL22104351 | 0.83 | EGFR (0.59) | EGFRCDK2CDK1CCNE1CDK7 | |
| SCHEMBL30556258 | 0.83 | EGFR (0.59) | EGFRCDK2CDK1CCNE1CDK7 | |
| SCHEMBL3048370 | 0.82 | CDK2 (0.59) | EGFRBRD4SLC2A1IGF1RKCNH2 | |
| SCHEMBL22089721 | 0.79 | EGFR (0.64) | EGFRIGF1RFLT3CDK2CDK1 | |
| SCHEMBL30556296 | 0.79 | EGFR (0.64) | EGFRIGF1RFLT3CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166110-B | 2-aminopyrimidine compound and application thereof | 暨南大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-113166110-A | 2-aminopyrimidine compounds and application thereof | 暨南大学 | 2021-07-23 | — | — | CN | disclosed |
| WO-2020119739-A1 | 2-AMINOPYRIMIDINE COMPOUND AND APPLICATION THEREFOR | 暨南大学 | 2020-06-18 | — | — | WO | disclosed |
| WO-2020119739-A1 | 2-AMINOPYRIMIDINE COMPOUND AND APPLICATION THEREFOR | 暨南大学 | 2020-06-18 | — | — | WO | disclosed |