Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.59 |
| ▸ | FLT3 | P36888 | 3/20 | 0.59 |
| ▸ | CDK1 | P06493 | 1/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.59 |
| ▸ | CDK7 | P50613 | 1/20 | 0.59 |
| ▸ | CCNH | P51946 | 1/20 | 0.59 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 3/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 4/20 | 0.54 |
| ▸ | CCND3 | P30281 | 4/20 | 0.54 |
| ▸ | GSK3B | P49841 | 4/20 | 0.54 |
| ▸ | PIM1 | P11309 | 3/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3042306 | 0.85 | FLT3 (0.78) | CDK2FLT3CDK1CCNB1CCNE1 | |
| SCHEMBL4499554 | 0.83 | IGF1R (0.64) | CDK2FLT3CDK1CCNB1CCNE1 | |
| SCHEMBL30556292 | 0.82 | EGFR (0.54) | CDK2FLT3CDK1CCNB1CCNE1 | |
| SCHEMBL22089640 | 0.82 | EGFR (0.54) | CDK2FLT3CDK1CCNB1CCNE1 | |
| SCHEMBL4510061 | 0.80 | FLT3 (0.56) | CDK2FLT3CDK1CCNB1CCNE1 | |
| SCHEMBL4506349 | 0.79 | FLT3 (0.77) | CDK2FLT3CDK1CCNB1CCNE1 | |
| SCHEMBL4518606 | 0.78 | CCNT1 (0.60) | CDK2FLT3CDK1CCNB1IGF1R | |
| SCHEMBL4510383 | 0.77 | FLT3 (0.64) | CDK2FLT3CDK1CCNB1EGFR | |
| SCHEMBL14719022 | 0.77 | EGFR (0.74) | CDK2FLT3CDK1CCNB1CCNE1 | |
| SCHEMBL30998031 | 0.77 | EGFR (0.72) | CDK2FLT3CDK1CCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267707-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-10-21 | — | — | US | claimed |
| US-20100267707-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-10-21 | — | — | US | disclosed |
| US-20100267707-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-10-21 | — | — | US | disclosed |
| US-20100267707-A1 | Tyrosine Kinase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-10-21 | — | — | US | disclosed |
| WO-2007149427-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267707-A1 | Tyrosine Kinase Inhibitors | ABL1, ERBB2, MET | CDK2 145/4885FLT3 11/4885CDK1 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.