SCHEMBL22091027

SCHEMBL22091027

O=C(On1c(=O)ccc2ccccc21)C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.42
BRD4 O60885 1/20 0.42
BRPF1 P55201 1/20 0.42
CA9 Q16790 1/20 0.42
KAT2B Q92831 1/20 0.42
BRD9 Q9H8M2 1/20 0.42
KMT2A Q03164 2/20 0.35
TRPV1 Q8NER1 1/20 0.33
NOTUM Q6P988 1/20 0.33
HDAC1 Q13547 3/20 0.33
HDAC6 Q9UBN7 3/20 0.33
HDAC8 Q9BY41 2/20 0.33
LMNA P02545 1/20 0.33
KDM4E B2RXH2 1/20 0.32
HTT P42858 1/20 0.32
TSHR P16473 1/20 0.32
RAB9A P51151 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
IDO1 P14902 1/20 0.31
DAO P14920 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4424854 0.82 CA12 (0.48) CA12BRD4BRPF1CA9KAT2B
SCHEMBL9496147 0.79 CA12 (0.50) CA12BRD4BRPF1CA9KAT2B
SCHEMBL27418562 0.79 CA12 (0.46) CA12BRD4BRPF1CA9KAT2B
SCHEMBL6998137 0.78 KMO (0.33) KDM4EHTTRAB9ADAO
SCHEMBL1972478 0.78 CA12 (0.44) CA12BRD4BRPF1CA9KAT2B
SCHEMBL10326300 0.78 CA12 (0.44) CA12BRD4BRPF1CA9KAT2B
SCHEMBL3291445 0.78 CA12 (0.44) CA12BRD4BRPF1CA9KAT2B
SCHEMBL16896766 0.77 CA12 (0.47) CA12BRD4BRPF1CA9KAT2B
SCHEMBL20377455 0.76 CA12 (0.43) CA12BRD4BRPF1CA9KAT2B
SCHEMBL5179763 0.76 CA12 (0.43) CA12BRD4BRPF1CA9KAT2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3894398-A1 3,3-DIFLUOROALLYLAMINES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME Yuhan Corporation (KR) 2021-10-20 EP disclosed
WO-2020121261-A1 3,3-DIFLUOROALLYLAMINES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME YUHAN CORPORATION (KR) 2020-06-18 WO disclosed