Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.48 |
| ▸ | PRKACA | P17612 | 7/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 6/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.48 |
| ▸ | CLK2 | P49760 | 6/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 6/20 | 0.48 |
| ▸ | GSK3A | P49840 | 6/20 | 0.48 |
| ▸ | GSK3B | P49841 | 6/20 | 0.48 |
| ▸ | CDK8 | P49336 | 5/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.48 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.48 |
| ▸ | PAK4 | O96013 | 4/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.48 |
| ▸ | CAMK2A | Q9UQM7 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22923901 | 0.80 | LRRK2 (0.54) | LRRK2ROCK1PRKACACDK5DYRK1A | |
| SCHEMBL27010942 | 0.79 | IRAK4 (0.43) | LRRK2ROCK1CDK5ROCK2JAK2 | |
| SCHEMBL26930189 | 0.77 | CAMKK2 (0.44) | LRRK2ROCK1PRKACACDK5DYRK1A | |
| SCHEMBL31735139 | 0.77 | CAMKK2 (0.44) | LRRK2ROCK1PRKACACDK5DYRK1A | |
| SCHEMBL29952060 | 0.76 | LRRK2 (0.50) | LRRK2ROCK1PRKACACDK5DYRK1A | |
| SCHEMBL23133692 | 0.76 | CCNK (0.43) | LRRK2ROCK1CDK5DYRK1AMAP4K4 | |
| SCHEMBL22304206 | 0.76 | JAK2 (0.38) | LRRK2ROCK1CDK5RPS6KA3ROCK2 | |
| SCHEMBL31735024 | 0.74 | LRRK2 (0.44) | LRRK2ROCK1PRKACACDK5DYRK1A | |
| SCHEMBL26953091 | 0.74 | LRRK2 (0.44) | LRRK2ROCK1PRKACACDK5DYRK1A | |
| SCHEMBL22304229 | 0.74 | LRRK2 (0.45) | LRRK2ROCK1PRKACACDK5PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10683278-B2 | Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof | SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) | 2020-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10683278-B2 | Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof | NRAS, AXL, ABL1 | LRRK2 597/4885ROCK1 322/4885PRKACA 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.