Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 8/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13471449 | 0.80 | TRPM8 (1.00) | TRPM8MAPK1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL22100750 | 0.79 | TRPM8 (0.76) | TRPM8MAPK1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL10270953 | 0.78 | TRPM8 (1.00) | TRPM8MAPK1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL22100762 | 0.77 | TRPM8 (0.50) | TRPM8MAPK1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL3783385 | 0.72 | TSHR (0.65) | TRPM8MAPK1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1926573 | 0.70 | RXRA (0.56) | KMT2AALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL2716971 | 0.68 | TRPM8 (0.57) | TRPM8MAPK1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2716968 | 0.68 | TRPM8 (0.57) | TRPM8MAPK1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2728401 | 0.68 | KDM4E (0.53) | MAPK1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2728405 | 0.68 | KDM4E (0.53) | MAPK1KMT2AALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501761-B1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2020-06-17 | — | — | EP | disclosed |