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Sugi Predict / Compounds / Succinic Acid

Succinic Acid

Succinic Acid

SCHEMBL2210128

Cc1nn(-c2c(Cl)ccc3c2CCNCC3)c(C)c1C.O=C(O)CCC(=O)O

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ HTR2C known ✓ P28335 10/20 0.39
▸ HTR2A known ✓ P28223 7/20 0.39
▸ HTR2B P41595 12/20 0.39
▸ PNMT P11086 2/20 0.33
▸ ADRA2A P08913 1/20 0.33
▸ ADRA2B P18089 1/20 0.33
▸ ADRA2C P18825 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ ALDH1A1 P00352 2/20 0.32
▸ KDM4E B2RXH2 1/20 0.31
▸ GLA P06280 1/20 0.31
▸ GAA P10253 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ P2RX7 Q99572 1/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ PKM P14618 1/20 0.31
▸ KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Succinic Acid SCHEMBL2210659 0.92 HTR2B (0.42) HTR2BHTR2CHTR2APNMTADRA2A
SCHEMBL12433766 0.90 HTR2C (0.48) HTR2BHTR2CHTR2APNMTADRA2A
Succinic Acid SCHEMBL2206275 0.83 ALDH1A1 (0.45) HTR2BHTR2CHTR2APNMTADRA2A
Succinic Acid SCHEMBL2210013 0.81 HTR2B (0.38) HTR2BHTR2CHTR2APNMTADRA2A
SCHEMBL12433770 0.81 HTR2C (0.51) HTR2BHTR2CHTR2APNMTADRA2A
Succinic Acid SCHEMBL2207859 0.79 ALDH1A1 (0.40) HTR2BHTR2CHTR2ANPC1RAB9A
Succinic Acid SCHEMBL2215481 0.77 HTR2B (0.46) HTR2BHTR2CHTR2A
Succinic Acid SCHEMBL2205533 0.77 HTR2B (0.39) HTR2BHTR2CHTR2A
Succinic Acid SCHEMBL2210626 0.76 HTR2C (0.37) HTR2BHTR2CHTR2APNMTADRA2A
Succinic Acid SCHEMBL2210644 0.76 HTR2C (0.46) HTR2BHTR2CHTR2APNMTADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1924578-B1 6-N-LINKED HETEROCYCLE-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS LILLY CO ELI (US) 2013-11-06 — — EP disclosed
US-7981882-B2 e.g. 7-Chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethanesulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine; antidepressant, anxiolytic agent; obesity, obsessive/compulsive disorder ELI LILLY AND COMPANY (US) 2011-07-19 — — US disclosed
US-20080214520-A1 6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists ELI LILLY AND COMPANY 2008-09-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080214520-A1 6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists HTR2C, HTR3B, HTR1A HTR2C 1/4885HTR2A 5/4885HTR2B 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.