Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 7/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | BAD | Q92934 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22990006 | 0.74 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL22102574 | 0.74 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL834706 | 0.74 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL15471189 | 0.74 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL23944932 | 0.72 | PARP1 (0.46) | PNMTPARP1BCL2L1BAD | |
| SCHEMBL3777343 | 0.70 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL29326087 | 0.69 | PNMT (0.40) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL23260194 | 0.69 | PNMT (0.40) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL20932959 | 0.69 | PNMT (0.40) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL197239 | 0.68 | ADRA2A (0.59) | PNMTADRA2AADRA2BADRA2CBCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020119592-A1 | NOVEL THREE-RING FUSED STRUCTURE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 信达生物制药(苏州)有限公司 | 2020-06-18 | — | — | WO | disclosed |