Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18437704 | 0.91 | ALDH1A1 (0.64) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL2212133 | 0.90 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL14799054 | 0.83 | SMN1; SMN2 (0.55) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL2210355 | 0.81 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL18437636 | 0.78 | ALDH1A1 (0.67) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL18438128 | 0.76 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| Sulfuric Acid SCHEMBL20984829 | 0.75 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL3322371 | 0.75 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL17978495 | 0.74 | FFAR4 (0.66) | ALDH1A1MEN1KMT2AMAPTPOLB | |
| SCHEMBL14383794 | 0.74 | ALDH1A1 (0.73) | ALDH1A1MEN1KMT2AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534284-B1 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2011-07-27 | — | — | EP | disclosed |
| US-7161031-B2 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2007-01-09 | — | — | US | disclosed |
| EP-1534284-A4 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-1534284-A2 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | Temple University of the Commonwealth System of Higher Education (US) | 2005-06-01 | — | — | EP | disclosed |
| US-20050096484-A1 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders | ONCONOVA THERAPEUTICS, INC. | 2005-05-05 | — | — | US | disclosed |
| WO-2003072063-A2 | AMINO-SUBSTITUTED SULFONANILIDES AND DERIVATIVES THEREOF FOR TREATING PROLIFERATIVE DISORDERS | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2003-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096484-A1 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders | ARSA, MKI67, CCNA1 | ALDH1A1 1651/4885MEN1 1780/4885KMT2A 913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.