Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | NPC1 | O15118 | 8/20 | 0.71 |
| ▸ | RAB9A | P51151 | 8/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.71 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.71 |
| ▸ | RELA | Q04206 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 9/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.66 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | CASP3 | P42574 | 1/20 | 0.63 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.63 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22103808 | 0.89 | TP53 (0.74) | TP53TSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5852140 | 0.85 | SAE1 (0.76) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL10192075 | 0.85 | KMT2A (0.71) | TP53TSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL4416620 | 0.85 | SMN1; SMN2 (0.77) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL29703055 | 0.85 | SMN1; SMN2 (0.77) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL5852120 | 0.84 | TP53 (0.82) | TP53TSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11011683 | 0.84 | TP53 (0.77) | TP53TSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4121731 | 0.84 | MAPT (0.72) | TP53NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4112132 | 0.84 | KMT2A (0.62) | TP53TSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL259602 | 0.83 | SMN1; SMN2 (0.75) | TP53TSHRNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020123675-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | DUKE UNIVERSITY (US) | 2020-06-18 | — | — | WO | disclosed |