Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 9/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | RAB9A | P51151 | 9/20 | 0.68 |
| ▸ | NPC1 | O15118 | 7/20 | 0.68 |
| ▸ | MITF | O75030 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.68 |
| ▸ | HTT | P42858 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | STAT1 | P42224 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.65 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.65 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31040569 | 0.92 | TP53 (0.87) | TP53TSHRMAPTKMT2AMEN1 | |
| SCHEMBL4893387 | 0.92 | TP53 (0.87) | TP53TSHRMAPTKMT2AMEN1 | |
| SCHEMBL17084260 | 0.90 | TP53 (0.84) | TP53TSHRMAPTKMT2AMEN1 | |
| SCHEMBL5852120 | 0.89 | TP53 (0.82) | TP53TSHRMAPTKMT2AMEN1 | |
| SCHEMBL22103809 | 0.89 | TP53 (0.77) | TP53TSHRMAPTKMT2AMEN1 | |
| SCHEMBL14442613 | 0.87 | TP53 (0.84) | TP53TSHRMAPTKMT2AMEN1 | |
| SCHEMBL4416620 | 0.86 | SMN1; SMN2 (0.77) | MAPTKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL29703055 | 0.86 | SMN1; SMN2 (0.77) | MAPTKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL6566850 | 0.84 | MAPT (0.73) | TP53TSHRMAPTKMT2AMEN1 | |
| SCHEMBL4118285 | 0.84 | CA2 (0.64) | TP53TSHRMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020123675-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | DUKE UNIVERSITY (US) | 2020-06-18 | — | — | WO | disclosed |