Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 6/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23939996 | 0.90 | PDGFRA (0.60) | FGFR2PDGFRAPDGFRBAXLKDR | |
| SCHEMBL23617110 | 0.90 | FGFR2 (0.67) | FGFR2PDGFRAAXLKDR | |
| SCHEMBL29822421 | 0.90 | FGFR2 (0.67) | FGFR2PDGFRAAXLKDR | |
| SCHEMBL23939997 | 0.88 | FGFR2 (0.52) | FGFR2PDGFRAPDGFRBAXLKDR | |
| SCHEMBL7480589 | 0.87 | FGFR2 (0.73) | FGFR2PDGFRAPDGFRBAXLKDR | |
| SCHEMBL26254832 | 0.85 | FGFR2 (0.62) | FGFR2PDGFRAPDGFRBAXLKDR | |
| SCHEMBL21769162 | 0.84 | MET (0.56) | FGFR2PDGFRAPDGFRBAXLKDR | |
| SCHEMBL21769414 | 0.84 | FGFR2 (0.54) | FGFR2PDGFRAPDGFRBKDR | |
| SCHEMBL22521159 | 0.82 | MET (0.63) | FGFR2AXLEGFRSRCTGFBR1 | |
| SCHEMBL22521192 | 0.82 | FGFR2 (0.59) | FGFR2PDGFRAAXLKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3896059-A1 | PAN-KIT KINASE INHIBITOR HAVING QUINOLINE STRUCTURE AND APPLICATION THEREOF | Tarapeutics Science Inc. (CN) | 2021-10-20 | — | — | EP | disclosed |
| WO-2020118753-A1 | PAN-KIT KINASE INHIBITOR HAVING QUINOLINE STRUCTURE AND APPLICATION THEREOF | 安徽中科拓苒药物科学研究有限公司 | 2020-06-18 | — | — | WO | disclosed |