Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.32 |
| ▸ | ITGAV | P06756 | 6/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 5/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2206230 | 0.85 | GPR119 (0.44) | GPR119TRPV1 | |
| SCHEMBL2204894 | 0.83 | GPR119 (0.42) | GPR119KMT2ATRPV1SMN1; SMN2MAPT | |
| SCHEMBL2208732 | 0.83 | GPR119 (0.46) | GPR119ITGB3ITGB1ITGAVITGA2B | |
| SCHEMBL4346000 | 0.81 | GPR119 (0.41) | GPR119ITGB3ITGB1ITGAVITGA2B | |
| SCHEMBL2208053 | 0.80 | GPR119 (0.46) | GPR119ITGB3ITGB1ITGAVITGA2B | |
| SCHEMBL2206338 | 0.77 | HDAC3 (0.40) | GPR119KMT2ATRPV1SMN1; SMN2MAPT | |
| SCHEMBL2209037 | 0.76 | GPR119 (0.43) | GPR119ITGB3ITGB1ITGAVITGA2B | |
| SCHEMBL2204827 | 0.72 | EPHX2 (0.48) | KMT2ATRPV1 | |
| SCHEMBL2205140 | 0.72 | EPHX2 (0.48) | KMT2ATRPV1 | |
| SCHEMBL2208558 | 0.72 | EPHX2 (0.48) | KMT2ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981883-B2 | Substituted spiro-compounds and the use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-07-19 | — | — | US | disclosed |
| US-20090275628-A1 | Substituted Spiro-Compounds And The Use Thereof For Producing Medicaments | GRUENENTHAL GMBH (DE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275628-A1 | Substituted Spiro-Compounds And The Use Thereof For Producing Medicaments | REN, PKD1, PKD2 | GPR119 3262/4885ENPP2 3012/4885KMT2A 3763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.