Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | BMP4 | P12644 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23438582 | 0.68 | KDM4E (0.41) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL609118 | 0.67 | MAPT (0.58) | KDM4EMAPTKMT2AMEN1CYP19A1 | |
| SCHEMBL27565565 | 0.67 | TBXAS1 (0.52) | KDM4EMAPTKMT2AMEN1CYP19A1 | |
| SCHEMBL16344606 | 0.67 | CYP3A4 (0.45) | KDM4EMAPTCYP19A1TBXAS1ALDH1A1 | |
| SCHEMBL4067924 | 0.67 | CDC7 (0.49) | KDM4EMAPTALDH1A1LMNACYP3A4 | |
| SCHEMBL2040804 | 0.66 | EGFR (0.46) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL30269650 | 0.66 | EGFR (0.46) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL4056820 | 0.66 | ALDH1A1 (0.44) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL16484326 | 0.66 | KDM4E (0.47) | KDM4EMAPTKMT2AMEN1CYP19A1 | |
| SCHEMBL21383713 | 0.65 | RPS6KA5 (0.40) | KDM4EMAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981893-B2 | Heteroaryl compounds, compositions thereof, and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2011-07-19 | — | — | US | claimed |