Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | BPTF | Q12830 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12871796 | 0.84 | PRMT5 (0.42) | PRMT5WDR77PDE2ABRD4PTK2 | |
| SCHEMBL12871465 | 0.83 | PRMT5 (0.43) | PRMT5WDR77PDE2ABRD4PTK2 | |
| SCHEMBL21051395 | 0.83 | ESR1 (0.40) | PRMT5WDR77PTK2CYP11B2SMN1; SMN2 | |
| SCHEMBL12871639 | 0.82 | FEN1 (0.44) | PRMT5WDR77PDE2ABRD4CREBBP | |
| SCHEMBL4835543 | 0.81 | ALDH1A1 (0.46) | PRMT5WDR77MAPK14SMN1; SMN2 | |
| SCHEMBL12871454 | 0.80 | ALDH1A1 (0.40) | PTK2SMN1; SMN2 | |
| SCHEMBL12871459 | 0.80 | PRMT5 (0.46) | PRMT5WDR77PDE2AHTR2AHTR2C | |
| SCHEMBL16201319 | 0.79 | PRMT6 (0.44) | PRMT5WDR77NR3C2PDE2AMAPK14 | |
| SCHEMBL3630473 | 0.78 | NR3C2 (0.41) | PRMT5WDR77NR3C2PDE2AMAPK14 | |
| SCHEMBL16201150 | 0.75 | PRMT1 (0.43) | PRMT5WDR77NR3C2PDE2AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3082819-B1 | SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2020-06-17 | — | — | EP | disclosed |