Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22110373 | 0.82 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC2HDAC4 | |
| SCHEMBL12472553 | 0.82 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC2HDAC4 | |
| SCHEMBL12938881 | 0.82 | HDAC6 (0.68) | HDAC6HDAC1HDAC8HDAC2HDAC4 | |
| SCHEMBL10413206 | 0.77 | L3MBTL1 (0.54) | HDAC6HDAC1HDAC8HDAC2HDAC9 | |
| SCHEMBL15705724 | 0.72 | HDAC6 (0.81) | HDAC6HDAC1HDAC8HDAC2HDAC9 | |
| SCHEMBL23951042 | 0.71 | HDAC6 (0.73) | HDAC6HDAC1HDAC8HDAC2HDAC4 | |
| SCHEMBL24031084 | 0.70 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC11 | |
| SCHEMBL29382989 | 0.70 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC11 | |
| SCHEMBL4056126 | 0.70 | HDAC6 (0.74) | HDAC6HDAC1HDAC8HDAC2HDAC9 | |
| SCHEMBL12472344 | 0.69 | HDAC6 (0.73) | HDAC6HDAC1HDAC8HDAC2HDAC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220401474-A1 | HDAC6-ACTIVATED MACROPHAGES, COMPOSITIONS, AND USES THEREOF | MEDSTAR HEALTH | 2022-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220401474-A1 | HDAC6-ACTIVATED MACROPHAGES, COMPOSITIONS, AND USES THEREOF | HDAC6, HDAC1, HDAC3 | HDAC6 1/4885HDAC1 2/4885HDAC8 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.