Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 6/20 | 0.47 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 5/20 | 0.32 |
| ▸ | STAT3 | P40763 | 2/20 | 0.31 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.30 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.30 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.30 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.30 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.30 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.30 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20879386 | 0.85 | DUT (0.51) | DUTP2RY6TOP2AP2RY2P2RY4 | |
| SCHEMBL25567944 | 0.85 | DUT (0.46) | DUTP2RY6TOP2A | |
| SCHEMBL24928459 | 0.83 | DUT (0.49) | DUTP2RY6TOP2AP2RY2P2RY4 | |
| SCHEMBL20879436 | 0.81 | DUT (0.48) | DUTP2RY6TOP2AP2RY2P2RY4 | |
| SCHEMBL22666153 | 0.81 | DUT (0.48) | DUTP2RY6TOP2AP2RY2P2RY4 | |
| SCHEMBL23808334 | 0.80 | SLC28A1 (0.40) | DUTP2RY6P2RY2P2RY4SLC28A1 | |
| SCHEMBL25401430 | 0.78 | DUT (0.45) | DUTP2RY6TOP2AP2RY14 | |
| SCHEMBL26273368 | 0.78 | DUT (0.45) | DUTP2RY6TOP2AP2RY14 | |
| SCHEMBL26289955 | 0.78 | DUT (0.45) | DUTP2RY6TOP2AP2RY14 | |
| SCHEMBL22241508 | 0.77 | DUT (0.43) | DUTP2RY6TOP2AP2RY2P2RY4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3738969-A1 | 2'-CHLORO AMINOPYRIMIDINONE AND PYRIMIDINE DIONE NUCLEOSIDES FOR USE IN TREATING PNEUMOVIRINAE VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2020-11-18 | — | — | EP | disclosed |
| EP-3183261-B1 | 2'-CHLORO AMINOPYRIMIDINONE AND PYRIMIDINE DIONE NUCLEOSIDES | GILEAD SCIENCES INC (US) | 2020-06-17 | — | — | EP | disclosed |