SCHEMBL2211096

SCHEMBL2211096

C=C(C)C(=O)SCC(C)SC(=O)C(=C)C

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18140855 0.78 TSHR (0.34) TSHR
SCHEMBL5889404 0.76
SCHEMBL1412650 0.73 ALDH1A1 (0.31)
SCHEMBL1412729 0.73 CA1 (0.30)
SCHEMBL1412737 0.73 TP53 (0.31) TSHR
SCHEMBL7057040 0.72
SCHEMBL5743940 0.72
SCHEMBL12225878 0.72
SCHEMBL18141551 0.71 TGFBR1 (0.33)
SCHEMBL18139295 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0745620-A1 Polymerisable compositions based on thio(meth)acrylate monomers, polymers having low yellowness index made from these compositions and ophthalmic lenses made therefrom ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 1996-12-04 EP claimed
US-7981944-B2 Mixture of acrylated esters; photoinitiators ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2011-07-19 US disclosed
US-7618141-B2 Polymerizable composition containing an odor masking agent and a perfume, an optical lens and a production method ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) 2009-11-17 US disclosed
EP-1629308-B1 PHOTOCURABLE ADHESIVE COMPOSITION AND ITS USE IN THE OPTICAL FIELD ESSILOR INT (FR) 2008-10-08 EP disclosed
EP-1608704-B1 THIOPHOSPHINE COMPOUNDS AND METHOD OF MAKING POLYMERISABLE COMPOSITIONS CONTAINING THEM AND THEIR USE FOR MAKING OPHTALMIC LENSES ESSILOR INT (FR) 2008-03-19 EP disclosed
US-20080013042-A1 Polymerizable Composition Containing An Odor Masking Agent And A Perfume, An Optical Lens And A Production Method ESSILOR INTERNATIONAL (FR) 2008-01-17 US disclosed
US-20070087123-A1 Photocurable adhesive composition and its use in the optical field ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2007-04-19 US disclosed
EP-0986590-B1 POLYMERISABLE COMPOSITION FOR MAKING OPTICAL LENS WITH HIGH REFRACTIVE INDEX AND HIGH ABBE NUMBER, AND RESULTING LENS ESSILOR INT (FR) 2004-01-21 EP disclosed
US-6635730-B1 Photopolymerizable composition forming lenses with low yellowing index and good resistance to aging ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2003-10-21 US disclosed
US-20030195270-A1 Enic compounds, sulfur-containing polyenic compound, sulfur-containing polythiol compound, high refractive index photocurable composition and cured product thereof ISHII KENJI (JP) 2003-10-16 US disclosed
US-6627718-B2 Polythio(meth)acrylate, bridged ethylenically unsaturated monomoer, and polythiol ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2003-09-30 US disclosed
US-20030109655-A1 Polymerizable compositions for making optical lens with high refractive index and high abbe number, and resulting lens ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2003-06-12 US disclosed
US-6479606-B1 Polymerizable compositions for making optical lens with high refractive index and high abbe number, and resulting lens ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2002-11-12 US disclosed
EP-0986767-B1 OPTICAL LENS IN TRANSPARENT ORGANIC POLYMER MATERIAL WITH HIGH REFRACTIVE INDEX AND HIGH ABBE NUMBER ESSILOR INT (FR) 2002-09-18 EP disclosed
EP-0994907-A1 NOVEL POLYMERISABLE COMPOSITIONS AND OPTICAL LENSES WITH HIGH REFRACTIVE INDEX OBTAINED FROM SAID COMPOSITIONS ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2000-04-26 EP disclosed
WO-1999002575-A1 NOVEL POLYMERISABLE COMPOSITIONS AND OPTICAL LENSES WITH HIGH REFRACTIVE INDEX OBTAINED FROM SAID COMPOSITIONS ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 1999-01-21 WO disclosed
EP-0745620-A1 Polymerisable compositions based on thio(meth)acrylate monomers, polymers having low yellowness index made from these compositions and ophthalmic lenses made therefrom ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 1996-12-04 EP disclosed
EP-0273710-B2 Resin having high refractive index, process for producing said resin and optical materials composed of said resin NIPPON CATALYTIC CHEM IND (JP) 1996-10-16 EP disclosed