Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13624780 | 0.86 | GAA (0.50) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL796619 | 0.84 | GAA (0.48) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL14268339 | 0.81 | TSHR (0.40) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL3913292 | 0.81 | TSHR (0.40) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL12295403 | 0.81 | TSHR (0.40) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL28539938 | 0.81 | L3MBTL1 (0.57) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL29613717 | 0.81 | ALOX15 (0.50) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL25660778 | 0.81 | L3MBTL1 (0.57) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL27400846 | 0.79 | GAA (0.43) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL27400858 | 0.79 | GAA (0.43) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666788-A1 | HEMIASTERLIN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES INCLUDING SAME | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2020-06-17 | — | — | EP | disclosed |