Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19956526 | 0.83 | ALDH1A1 (0.31) | ALDH1A1TDP1 | |
| SCHEMBL23030366 | 0.82 | ACE (0.39) | ALDH1A1KDM4EMAPTTHRBALOX15 | |
| SCHEMBL25571234 | 0.81 | FOLH1 (0.31) | ALDH1A1TDP1 | |
| SCHEMBL13078293 | 0.80 | KDM4E (0.47) | ALDH1A1TDP1KDM4EMAPTTHRB | |
| SCHEMBL13164033 | 0.79 | KDM4E (0.31) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL25772886 | 0.78 | ACE (0.37) | ALDH1A1TDP1KDM4EMAPTTHRB | |
| SCHEMBL20738902 | 0.78 | ALDH1A1 (0.31) | ALDH1A1TDP1 | |
| SCHEMBL12249240 | 0.78 | KISS1R (0.32) | — | |
| SCHEMBL13474987 | 0.78 | ALDH1A1 (0.43) | ALDH1A1TDP1 | |
| SCHEMBL12157037 | 0.78 | ALDH1A1 (0.43) | ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666788-A1 | HEMIASTERLIN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES INCLUDING SAME | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2020-06-17 | — | — | EP | disclosed |