Sugi Predict

Sugi Predict / Compounds / Succinic Acid

Succinic Acid

Succinic Acid

SCHEMBL2211440

Clc1ccc2c(c1-n1nccc1-c1cccnc1)CCNCC2.O=C(O)CCC(=O)O

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR2A known ✓ P28223 2/20 0.34
▸ HTR2C known ✓ P28335 2/20 0.34
▸ CYP11B2 P19099 4/20 0.35
▸ HTR2B P41595 1/20 0.34
▸ MKNK1 Q9BUB5 1/20 0.34
▸ MKNK2 Q9HBH9 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ KDM4C Q9H3R0 2/20 0.33
▸ KDM5B Q9UGL1 2/20 0.33
▸ KDM6B O15054 1/20 0.33
▸ NR1I2 O75469 1/20 0.33
▸ CHRNA1 P02708 1/20 0.33
▸ MAOB P27338 1/20 0.33
▸ OPRM1 P35372 1/20 0.33
▸ AHR P35869 1/20 0.33
▸ AVPR1A P37288 1/20 0.33
▸ OPRK1 P41145 1/20 0.33
▸ PDE4B Q07343 1/20 0.33
▸ SCN5A Q14524 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Succinic Acid SCHEMBL2209062 0.91 HTR2B (0.38) HTR2AHTR2CHTR2BKDM4CKDM5B
SCHEMBL12433855 0.91 HTR2A (0.41) CYP11B2HTR2AHTR2CHTR2BMKNK1
Succinic Acid SCHEMBL2207455 0.89 HTR2A (0.37) HTR2AHTR2CHTR2BKDM4CKDM5B
Succinic Acid SCHEMBL2209304 0.86 KDM5A (0.44) HTR2AHTR2CHTR2BKDM4CKDM5B
Succinic Acid SCHEMBL2209289 0.85 KDM5A (0.39) HTR2AHTR2CHTR2BALDH1A1KDM4C
Succinic Acid SCHEMBL2206649 0.84 HTR2A (0.35) HTR2AHTR2CHTR2BKDM4CKDM5B
Succinic Acid SCHEMBL2208833 0.84 MAPK1 (0.40) KDM4CKDM5BPDE4BKDM5A
Succinic Acid SCHEMBL2205175 0.84 ASIC3 (0.39) HTR2CHTR2BPARP10PARP11
Succinic Acid SCHEMBL2205633 0.83 HTR2A (0.34) HTR2AHTR2CHTR2BKDM4CKDM5B
Succinic Acid SCHEMBL2210645 0.83 RPA1 (0.37) HTR2AHTR2CHTR2BMKNK1MKNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1924578-B1 6-N-LINKED HETEROCYCLE-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS LILLY CO ELI (US) 2013-11-06 — — EP disclosed
US-7981882-B2 e.g. 7-Chloro-3-(2,2,2-trifluoroacetyl)-6-trifluoromethanesulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine; antidepressant, anxiolytic agent; obesity, obsessive/compulsive disorder ELI LILLY AND COMPANY (US) 2011-07-19 — — US disclosed
US-20080214520-A1 6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists ELI LILLY AND COMPANY 2008-09-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080214520-A1 6-N-Linked Heterocycle-Substituted 2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists HTR2C, HTR3B, HTR1A HTR2A 5/4885HTR2C 1/4885CYP11B2 937/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.