Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | ALPG | P10696 | 1/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | NPY1R | P25929 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | NPY2R | P49146 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25239903 | 0.91 | ALDH1A1 (0.79) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL25286621 | 0.91 | ALDH1A1 (0.72) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL2381086 | 0.90 | ALDH1A1 (0.77) | ALDH1A1MEN1KMT2AMAPTGAA | |
| Hydrogen Peroxide SCHEMBL8527081 | 0.87 | ALDH1A1 (0.82) | ALDH1A1MEN1KMT2AMAPTGAA | |
| Water SCHEMBL22228992 | 0.87 | ALDH1A1 (0.74) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL3641455 | 0.82 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL8137569 | 0.81 | ALDH1A1 (0.64) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL5573059 | 0.81 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL3322327 | 0.80 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL4162470 | 0.80 | ALDH1A1 (0.95) | ALDH1A1MEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402324-A | Method for rapidly synthesizing microporous organic network material by ultrasonic assistance | 山东第一医科大学(山东省医学科学院) | 2024-01-16 | — | — | CN | claimed |
| CN-117402324-A | Method for rapidly synthesizing microporous organic network material by ultrasonic assistance | 山东第一医科大学(山东省医学科学院) | 2024-01-16 | — | — | CN | disclosed |
| US-11731965-B2 | Tetrahydroprotoberberine compound, preparation method therefor and uses thereof, and pharmaceutical composition | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2023-08-22 | — | — | US | disclosed |
| EP-3978497-A1 | FUSED RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2022-04-06 | — | — | EP | disclosed |
| US-20200255421-A1 | TETRAHYDROPROTOBERBERINE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF, AND PHARMACEUTICAL COMPOSITION | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2020-08-13 | — | — | US | disclosed |
| EP-3670511-A1 | TETRAHYDROPROTOBERBERINE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF, AND PHARMACEUTICAL COMPOSITION | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-06-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255421-A1 | TETRAHYDROPROTOBERBERINE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF, AND PHARMACEUTICAL COMPOSITION | NOTUM, BHMT, CYP4F11 | ALDH1A1 446/4885MEN1 964/4885KMT2A 3473/4885 |
| US-11731965-B2 | Tetrahydroprotoberberine compound, preparation method therefor and uses thereof, and pharmaceutical composition | NOTUM, BHMT, CYP4F11 | ALDH1A1 446/4885MEN1 964/4885KMT2A 3473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.