Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 18/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22116414 | 0.84 | ABL1 (0.43) | ACACBKIF18A | |
| SCHEMBL22116366 | 0.84 | ABL1 (0.43) | ACACBKIF18A | |
| SCHEMBL30611688 | 0.84 | ABL1 (0.43) | ACACBKIF18A | |
| SCHEMBL30611680 | 0.84 | ABL1 (0.43) | ACACBKIF18A | |
| SCHEMBL22116346 | 0.81 | KIF18A (0.50) | KIF18A | |
| SCHEMBL22116413 | 0.81 | HPGD (0.39) | ACACBTYK2KIF18A | |
| SCHEMBL22116332 | 0.78 | HSD11B1 (0.44) | ACACBKIF18A | |
| SCHEMBL30611713 | 0.78 | PTGER4 (0.42) | KIF18A | |
| SCHEMBL22116307 | 0.78 | KIF18A (0.42) | ACACBTYK2KIF18A | |
| SCHEMBL30611793 | 0.78 | KIF18A (0.42) | ACACBTYK2KIF18A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897832-A1 | N-(PYRIDIN-2-YLSULFONYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF A CFTR MEDIATED DISEASE | Novartis AG (CH) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020128768-A1 | N-(PYRIDIN-2-YLSULFONYL)CYCLOPROPANECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF A CFTR MEDIATED DISEASE | NOVARTIS AG (CH) | 2020-06-25 | — | — | WO | disclosed |