Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.32 |
| ▸ | CLPP | Q16740 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22118806 | 0.90 | PDE5A (0.36) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL22118847 | 0.89 | PDE5A (0.35) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL22118923 | 0.88 | PDE5A (0.35) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL22118854 | 0.82 | RNASEH1 (0.34) | RNASEH1 | |
| SCHEMBL22118836 | 0.80 | PDE9A (0.37) | PDE5APDE9APDE1APDE1BPDE1C | |
| SCHEMBL22118862 | 0.79 | PARP1 (0.40) | CTSLPDE5APDE9APDE1APDE1B | |
| SCHEMBL22118859 | 0.78 | RNASEH1 (0.33) | RNASEH1 | |
| SCHEMBL22119381 | 0.77 | RNASEH1 (0.34) | RNASEH1 | |
| SCHEMBL22118809 | 0.76 | RNASEH1 (0.33) | RNASEH1 | |
| SCHEMBL22118821 | 0.75 | MAPT (0.34) | RNASEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897645-A1 | DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF | Acurx Pharmaceuticals, LLC (US) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020132174-A1 | DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF | ACURX PHARMACEUTICALS, LLC (US) | 2020-06-25 | — | — | WO | disclosed |