⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214311 | 0.83 | KCNK9 (0.44) | — | |
| SCHEMBL2213715 | 0.83 | SMN1; SMN2 (0.38) | — | |
| SCHEMBL2214272 | 0.82 | MAP3K5 (0.39) | — | |
| SCHEMBL2215043 | 0.82 | F2 (0.39) | — | |
| SCHEMBL2215249 | 0.82 | SMN1; SMN2 (0.37) | — | |
| SCHEMBL2213042 | 0.81 | LMNA (0.37) | — | |
| SCHEMBL2215156 | 0.81 | KDM4E (0.37) | — | |
| SCHEMBL2216183 | 0.80 | ALDH1A1 (0.42) | — | |
| SCHEMBL2215221 | 0.79 | MAPT (0.42) | — | |
| SCHEMBL2214233 | 0.79 | DNMT1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797096-B1 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF PROTEIN KINASE B (AKT) | BAYER SCHERING PHARMA AG (DE) | 2011-07-27 | — | — | EP | disclosed |
| US-7745446-B2 | Pyrazolo[1,5-c]pyrimidines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-29 | — | — | US | disclosed |
| US-20070254046-A1 | Novel Pyrazolopyrimidines | ALTANA PHARMA AG (DE) | 2007-11-01 | — | — | US | disclosed |
| EP-1797096-A2 | NOVEL PYRAZOLOPYRIMIDINES | Altana Pharma AG (DE) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006027346-A2 | NOVEL PYRAZOLOPYRIMIDINES | ALTANA PHARMA AG (DE) | 2006-03-16 | — | — | WO | disclosed |