Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 9/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 9/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22119641 | 0.86 | TSHR (0.50) | DDB1CRBNNPC1GAATSHR | |
| SCHEMBL28629401 | 0.85 | DDB1 (0.58) | DDB1CRBNNPC1RAB9AMAPT | |
| SCHEMBL22119499 | 0.85 | DDB1 (0.58) | DDB1CRBNNPC1RAB9AMAPT | |
| SCHEMBL22144678 | 0.85 | DDB1 (0.47) | DDB1CRBNGAATSHR | |
| SCHEMBL27363599 | 0.78 | DDB1 (0.58) | DDB1CRBN | |
| SCHEMBL23538658 | 0.77 | DDB1 (0.69) | DDB1CRBNMAPT | |
| SCHEMBL31447706 | 0.77 | DDB1 (0.53) | DDB1CRBN | |
| SCHEMBL23551338 | 0.76 | DDB1 (0.59) | DDB1CRBNDRD2DRD4DRD3 | |
| SCHEMBL31323798 | 0.76 | DDB1 (0.59) | DDB1CRBNDRD2DRD4DRD3 | |
| SCHEMBL23539324 | 0.75 | DDB1 (0.59) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897631-A1 | TARGETED PROTEIN DEGRADATION | C4 Therapeutics, Inc. (US) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020132561-A1 | TARGETED PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2020-06-25 | — | — | WO | disclosed |