Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.44 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23539324 | 0.89 | DDB1 (0.59) | DDB1CRBNHDAC3HDAC1HDAC2 | |
| SCHEMBL22119482 | 0.86 | DDB1 (0.44) | TSHRGAADDB1CRBNIDO1 | |
| SCHEMBL28638009 | 0.84 | DDB1 (0.64) | TSHRGAADDB1CRBNNAMPT | |
| SCHEMBL22119702 | 0.84 | DDB1 (0.64) | TSHRGAADDB1CRBNNAMPT | |
| Trifluoroacetic Acid SCHEMBL30207617 | 0.83 | DDB1 (0.53) | DDB1CRBNHDAC3HDAC1HDAC2 | |
| SCHEMBL22144430 | 0.79 | GAA (0.57) | TSHRGAADDB1CRBNNAMPT | |
| SCHEMBL23799146 | 0.78 | DDB1 (0.55) | DDB1CRBNHDAC3HDAC1HDAC2 | |
| SCHEMBL30376705 | 0.78 | DDB1 (0.59) | DDB1CRBNHDAC3HDAC1HDAC2 | |
| SCHEMBL6940107 | 0.78 | GAA (0.75) | TSHRGAADDB1CRBN | |
| SCHEMBL31323602 | 0.76 | DDB1 (0.52) | DDB1CRBNNAMPTHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3897631-A1 | TARGETED PROTEIN DEGRADATION | C4 Therapeutics, Inc. (US) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020132561-A1 | TARGETED PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2020-06-25 | — | — | WO | disclosed |