Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 4/20 | 0.44 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.44 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2882272 | 0.95 | FYN (0.48) | FYNPIP4K2APIP4K2BCYP17A1CYP11B1 | |
| SCHEMBL2882567 | 0.90 | RAD52 (0.47) | FYNPIP4K2APIP4K2BCYP17A1CYP11B1 | |
| SCHEMBL2214072 | 0.84 | FYN (0.50) | FYNRAD52MAPTMEN1KMT2A | |
| SCHEMBL2876715 | 0.83 | PLCG1 (0.43) | MAPTMEN1KMT2ATP53RAB9A | |
| SCHEMBL2882294 | 0.81 | FYN (0.48) | FYNPIP4K2APIP4K2BCYP17A1CYP11B1 | |
| SCHEMBL2882015 | 0.79 | CYP17A1 (0.47) | FYNCYP17A1CYP11B1CYP11B2RAD52 | |
| SCHEMBL2214081 | 0.78 | SCD (0.42) | CA2MAPTMEN1KMT2ACYP2C19 | |
| SCHEMBL2213858 | 0.78 | CDK2 (0.42) | CA2MAPTMEN1KMT2ATP53 | |
| SCHEMBL2209540 | 0.76 | BPTF (0.36) | MAPTMEN1KMT2ACYP2C19CYP1A2 | |
| SCHEMBL2214323 | 0.75 | ALDH1A1 (0.41) | CA2MAPTMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797096-B1 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF PROTEIN KINASE B (AKT) | BAYER SCHERING PHARMA AG (DE) | 2011-07-27 | — | — | EP | disclosed |