Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.41 |
| ▸ | CAMKK1 | Q8N5S9 | 2/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | IL1B | P01584 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 8/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 8/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30604222 | 0.80 | DHODH (0.58) | LMNACYP19A1CAMKK2CAMKK1ACVR1 | |
| SCHEMBL24532382 | 0.80 | DHODH (0.58) | LMNACYP19A1CAMKK2CAMKK1ACVR1 | |
| SCHEMBL3850885 | 0.79 | TLR8 (0.46) | ACVR1DYRK1B | |
| SCHEMBL24532563 | 0.77 | LMNA (0.49) | LMNACYP19A1CAMKK2CAMKK1ACVR1 | |
| SCHEMBL30604126 | 0.77 | LMNA (0.49) | LMNACYP19A1CAMKK2CAMKK1ACVR1 | |
| SCHEMBL3852053 | 0.76 | ACVR1 (0.44) | ACVR1DYRK1B | |
| SCHEMBL3852118 | 0.74 | DPP4 (0.41) | — | |
| SCHEMBL22119808 | 0.74 | KDM4E (0.53) | LMNACAMKK2CAMKK1ACVR1KDM4E | |
| Hydrochloric Acid SCHEMBL3846129 | 0.74 | TDO2 (0.42) | ACVR1 | |
| SCHEMBL3854528 | 0.74 | DPP4 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898654-A2 | INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN | Praxis Biotech LLC (US) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020132661-A2 | INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN | Praxis Biotech LLC (US) | 2020-06-25 | — | — | WO | disclosed |