Sugi Predict

Sugi Predict / Compounds / SCHEMBL2212207

SCHEMBL2212207

SCHEMBL2212207

NC(=O)c1nc(Cl)ccc1Cl

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.47
▸ ALDH1A1 P00352 3/20 0.47
▸ GAA P10253 2/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ KDM4E B2RXH2 1/20 0.43
▸ L3MBTL1 Q9Y468 3/20 0.41
▸ CRHBP P24387 1/20 0.41
▸ CRHR2 Q13324 1/20 0.41
▸ IKBKB O14920 2/20 0.40
▸ LMNA P02545 2/20 0.39
▸ F2 P00734 1/20 0.39
▸ CTSA P10619 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ ATM Q13315 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31141501 1.00 KMT2A (0.47) KMT2AALDH1A1GAAMEN1KDM4E
Clopyralid SCHEMBL29371357 0.82 KMT2A (0.50) KMT2AALDH1A1GAAMEN1KDM4E
Clopyralid SCHEMBL8535196 0.82 KMT2A (0.50) KMT2AALDH1A1GAAMEN1KDM4E
Clopyralid SCHEMBL54779 0.82 KMT2A (0.50) KMT2AALDH1A1GAAMEN1KDM4E
Clopyralid SCHEMBL1698170 0.81 KMT2A (0.47) KMT2AALDH1A1GAAMEN1KDM4E
SCHEMBL668419 0.81 MAP2K3 (0.53) KMT2AALDH1A1GAAMEN1IKBKB
SCHEMBL18941668 0.81 KMT2A (0.41) KMT2AALDH1A1GAAMEN1KDM4E
Clopyralid SCHEMBL2403527 0.80 KMT2A (0.49) KMT2AALDH1A1GAAMEN1KDM4E
SCHEMBL18784171 0.80 KMT2A (0.49) KMT2AALDH1A1GAAMEN1KDM4E
Clopyralid SCHEMBL5934004 0.80 KMT2A (0.49) KMT2AALDH1A1GAAMEN1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102875455-A Synthesis process of 3, 6-dichloro-2-aminopyridine UNIV XIHUA 2013-01-16 — — CN claimed
EP-3896065-A1 2-(HET)ARYL-SUBSTITUTED CONDENSED HETEROCYCLE DERIVATIVES AS PESTICIDES Bayer CropScience Aktiengesellschaft (DE) 2021-10-20 — — EP disclosed
EP-3896066-A2 2-(HET)ARYL-SUBSTITUTED CONDENSED HETEROCYCLE DERIVATIVES AS PESTICIDES Bayer CropScience Aktiengesellschaft (DE) 2021-10-20 — — EP disclosed
EP-3331870-B1 2-(HET)ARYL-SUBSTITUTED CONDENSED HETEROCYCLE DERIVATIVES AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2021-06-16 — — EP disclosed
US-10986840-B2 2-(het)aryl-substituted fused heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2021-04-27 — — US disclosed
US-10752624-B2 Kinase inhibitors ORIGENIS GMBH (DE) 2020-08-25 — — US disclosed
US-10667517-B2 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-06-02 — — US disclosed
US-20200029567-A1 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-01-30 — — US disclosed
CN-106458907-B Method for producing 3- (alkylsulfonyl) pyridine-2-carboxylic acid 住友化学株式会社 2018-12-11 — — CN disclosed
US-20180305356-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2018-10-25 — — US disclosed
WO-2014060112-A1 PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 — — WO disclosed
WO-2014060113-A1 NOVEL KINASE INHIBITORS ORIGENIS GMBH (DE) 2014-04-24 — — WO disclosed
US-20130085156-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES MSD K.K. (JP) 2013-04-04 — — US disclosed
CN-102875455-A Synthesis process of 3, 6-dichloro-2-aminopyridine UNIV XIHUA 2013-01-16 — — CN disclosed
US-8344003-B2 2-pyridinecarboxamide derivatives MSD K. K. (JP) 2013-01-01 — — US disclosed
EP-1598349-B1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES MSD KK (JP) 2011-07-27 — — EP disclosed
US-20100041660-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES MSD K.K. (JP) 2010-02-18 — — US disclosed
US-7629362-B2 2-pyridine carboxamide derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 2009-12-08 — — US disclosed
US-20060258701-A1 Novel 2-pyridinecarboxamide derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 2006-11-16 — — US disclosed
EP-1598349-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 2005-11-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10667517-B2 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides CYP1A1, CYP8B1, CYP1B1 KMT2A 2845/4885ALDH1A1 268/4885GAA 2302/4885
US-20200029567-A1 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides CYP1A1, CYP8B1, CYP1B1 KMT2A 2845/4885ALDH1A1 268/4885GAA 2302/4885
US-10986840-B2 2-(het)aryl-substituted fused heterocycle derivatives as pesticides CYP1A1, CYP8B1, CYP1B1 KMT2A 2845/4885ALDH1A1 268/4885GAA 2302/4885
US-20180305356-A1 NOVEL KINASE INHIBITORS LRRK2, MYLK2, MYLK KMT2A 921/4885ALDH1A1 4333/4885GAA 742/4885
US-20130085156-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES GCKR, GCK, HK2 KMT2A 1297/4885ALDH1A1 1207/4885GAA 481/4885
US-10752624-B2 Kinase inhibitors LRRK2, MYLK2, MYLK KMT2A 929/4885ALDH1A1 4184/4885GAA 698/4885
US-20060258701-A1 Novel 2-pyridinecarboxamide derivatives GCKR, GCK, HK2 KMT2A 1311/4885ALDH1A1 1249/4885GAA 482/4885
US-20100041660-A1 NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES GCKR, GCK, HK2 KMT2A 1297/4885ALDH1A1 1207/4885GAA 481/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.