Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | RECQL | P46063 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3169074 | 0.99 | PTGS1 (0.74) | PTGS1PTGS2MEN1KMT2ARECQL | |
| SCHEMBL13757326 | 0.81 | PTGS1 (0.58) | PTGS1PTGS2MEN1KMT2ARECQL | |
| SCHEMBL13532154 | 0.77 | NPC1 (0.61) | PTGS1PTGS2MEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL3182589 | 0.76 | NPC1 (0.60) | PTGS1PTGS2MEN1KMT2AMAPT | |
| SCHEMBL6582639 | 0.73 | RAB9A (1.00) | MEN1KMT2AKDM4EMAPTNPC1 | |
| SCHEMBL1143708 | 0.73 | RAB9A (1.00) | PTGS1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL25407314 | 0.72 | PTGS1 (0.56) | PTGS1PTGS2MEN1KMT2AKDM4E | |
| SCHEMBL4263645 | 0.71 | RAB9A (0.61) | PTGS1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL224624 | 0.71 | CYP1A2 (0.72) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL28906662 | 0.71 | RAB9A (1.00) | PTGS1MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866302-B1 | PYRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2011-07-27 | — | — | EP | disclosed |
| US-7767696-B2 | Antitumor agents; tyrosine inhbitor; controllling kinase signal transduction | MERCK PATENT GMBH (DE) | 2010-08-03 | — | — | US | disclosed |
| US-20100016319-A1 | ARYLMETHYLENE UREA DERIVATIVE AND USE THEREOF | TORAY INDUSTRIES, INC. A CORPORATION OF JAPAN (JP) | 2010-01-21 | — | — | US | disclosed |
| US-20100016319-A1 | ARYLMETHYLENE UREA DERIVATIVE AND USE THEREOF | TORAY INDUSTRIES, INC. A CORPORATION OF JAPAN (JP) | 2010-01-21 | — | — | US | disclosed |
| CN-101316841-A | Arylmethylene urea derivative and use thereof | TORAY INDUSTRIES (JP) | 2008-12-03 | — | — | CN | disclosed |
| EP-1970375-A1 | ARYLMETHYLENE UREA DERIVATIVE AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2008-09-17 | — | — | EP | disclosed |
| US-20080207699-A1 | Pyrazole Derivatives | MERCK PATENT GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
| EP-1866302-A1 | PYRAZOLE DERIVATIVES | Merck Patent GmbH (DE) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105844-A1 | PYRAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2006-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207699-A1 | Pyrazole Derivatives | TIE1, FER, RAF1 | PTGS1 1799/4885PTGS2 1022/4885MEN1 377/4885 |
| US-20100016319-A1 | ARYLMETHYLENE UREA DERIVATIVE AND USE THEREOF | UROD, UTS2R, SLC14A1 | PTGS1 319/4885PTGS2 261/4885MEN1 3856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.