Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2208187 | 0.95 | HRH3 (0.48) | HRH3MCHR1SCD5RIPK1 | |
| SCHEMBL2214389 | 0.87 | HRH3 (0.52) | HRH3MCHR1 | |
| SCHEMBL2206395 | 0.85 | HRH3 (0.48) | HRH3MCHR1 | |
| SCHEMBL1377937 | 0.82 | HRH3 (0.65) | HRH3 | |
| SCHEMBL2209044 | 0.82 | HRH3 (0.58) | HRH3MCHR1 | |
| SCHEMBL2213063 | 0.81 | HRH3 (0.48) | HRH3MCHR1 | |
| SCHEMBL2208759 | 0.81 | MCHR1 (0.47) | HRH3MCHR1 | |
| SCHEMBL2212421 | 0.80 | HRH3 (0.47) | HRH3MCHR1 | |
| SCHEMBL2206388 | 0.80 | HRH3 (0.58) | HRH3MCHR1 | |
| SCHEMBL2210609 | 0.80 | HRH3 (0.58) | HRH3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805166-B1 | QUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-27 | — | — | EP | claimed |