Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | POLR1A | O95602 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1377383 | 0.88 | PDE3B (0.52) | PDE3BPDE3AHRH3SCN9A | |
| SCHEMBL2209226 | 0.86 | HRH3 (0.51) | PDE3BPDE3AHRH3SCN9A | |
| SCHEMBL2211917 | 0.83 | HRH3 (0.46) | PDE3BPDE3AHRH3ATMCHRM3 | |
| SCHEMBL2211145 | 0.78 | HRH3 (0.58) | HRH3 | |
| SCHEMBL2206296 | 0.77 | HRH3 (0.52) | HRH3 | |
| SCHEMBL1377269 | 0.76 | HRH3 (0.59) | PDE3BPDE3AHRH3SCN9A | |
| SCHEMBL2209038 | 0.74 | HRH3 (0.59) | HRH3SCN9A | |
| SCHEMBL2208645 | 0.74 | HRH3 (0.58) | PDE3BPDE3AHRH3SCN9AATM | |
| SCHEMBL2211945 | 0.72 | HRH3 (0.54) | HRH3 | |
| SCHEMBL1377891 | 0.72 | HRH3 (0.48) | PDE3BPDE3AHRH3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805166-B1 | QUINOLINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-27 | — | — | EP | claimed |