Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 14/20 | 0.38 |
| ▸ | ALPL | P05186 | 3/20 | 0.37 |
| ▸ | ALPI | P09923 | 3/20 | 0.37 |
| ▸ | ALPG | P10696 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2212577 | 0.88 | GCK (0.49) | GCKALPLALPIALPGNPC1 | |
| SCHEMBL2213431 | 0.85 | GCK (0.39) | GCKALPLALPIALPGRAB9A | |
| SCHEMBL2212703 | 0.85 | ALPL (0.36) | GCKALPLALPIALPGNPC1 | |
| SCHEMBL2213977 | 0.83 | GCK (0.40) | GCKALPLALPIALPGNPC1 | |
| SCHEMBL2211540 | 0.82 | GCK (0.42) | GCK | |
| SCHEMBL2212536 | 0.82 | GCK (0.52) | GCK | |
| SCHEMBL2211348 | 0.82 | GCK (0.59) | GCKALPLALPIALPGNPC1 | |
| SCHEMBL2213895 | 0.79 | GCK (0.44) | GCKNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL2642970 | 0.75 | GCK (0.50) | GCKL3MBTL1 | |
| SCHEMBL2663244 | 0.74 | GCK (0.41) | GCKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1598349-B1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | MSD KK (JP) | 2011-07-27 | — | — | EP | claimed |