Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 17/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2210566 | 0.88 | GCK (0.44) | GCK | |
| SCHEMBL2211348 | 0.87 | GCK (0.59) | GCKNPC1RAB9A | |
| SCHEMBL2211415 | 0.85 | GCK (0.54) | GCKNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2212536 | 0.84 | GCK (0.52) | GCKADORA3 | |
| SCHEMBL2211540 | 0.83 | GCK (0.42) | GCK | |
| SCHEMBL2213440 | 0.79 | GCK (0.38) | GCKNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2211357 | 0.79 | GCK (0.55) | GCKADORA3MEN1NPC1MAPT | |
| SCHEMBL2215580 | 0.76 | GCK (0.55) | GCK | |
| SCHEMBL2642911 | 0.75 | GCK (0.75) | GCKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2211857 | 0.74 | GCK (0.53) | GCKMEN1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1598349-B1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | MSD KK (JP) | 2011-07-27 | — | — | EP | claimed |