Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 4/20 | 0.56 |
| ▸ | JAK1 | P23458 | 4/20 | 0.56 |
| ▸ | TYK2 | P29597 | 4/20 | 0.56 |
| ▸ | JAK3 | P52333 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22135974 | 0.84 | STING1 (0.52) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL22136152 | 0.81 | STING1 (0.65) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL19437515 | 0.78 | KMT2A (0.63) | POLBJAK2JAK1TYK2JAK3 | |
| SCHEMBL22118178 | 0.75 | STING1 (0.66) | POLBJAK2JAK1TYK2JAK3 | |
| SCHEMBL22136297 | 0.74 | STING1 (0.59) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL22135904 | 0.74 | STING1 (0.62) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL5598387 | 0.74 | KMT2A (0.72) | POLBJAK2JAK1TYK2JAK3 | |
| SCHEMBL22136149 | 0.74 | STING1 (0.64) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL22135906 | 0.73 | STING1 (0.61) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL22135975 | 0.73 | STING1 (0.61) | JAK2JAK1TYK2JAK3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132549-A1 | STING HETEROCYCLE AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |