Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | JAK2 | O60674 | 10/20 | 0.60 |
| ▸ | JAK1 | P23458 | 10/20 | 0.60 |
| ▸ | TYK2 | P29597 | 10/20 | 0.60 |
| ▸ | JAK3 | P52333 | 10/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 3/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | FGB | P02675 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24688431 | 0.87 | KMT2A (0.61) | KMT2AKDM4EHDAC6THRBPTGER4 | |
| SCHEMBL18191353 | 0.84 | KMT2A (1.00) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL19437503 | 0.84 | KMT2A (0.74) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL24688398 | 0.83 | KDM4E (0.74) | KMT2AKDM4EHDAC6PTGER4MEN1 | |
| SCHEMBL22533357 | 0.81 | KMT2A (0.52) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL27442475 | 0.80 | KMT2A (0.51) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL6445182 | 0.79 | HSD17B10 (0.59) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL6445163 | 0.79 | JAK2 (0.76) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL19437515 | 0.76 | KMT2A (0.63) | KMT2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL13677356 | 0.75 | NLRP3 (0.60) | KMT2AKDM4EMEN1ALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007091950-A1 | BENZIMIDAZOLES AND IMIDAZOPYRIDINES USEFUL IN THE TREATMENT OF DISEASES OR DISORDERS ASSOCIATED WITH CANNABINOID RECEPTOR 2 (CB2) SUCH AS PAIN | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | WO | disclosed |