Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.52 |
| ▸ | SPR | P35270 | 9/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557776 | 0.85 | KDM4E (0.70) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| Hydrochloric Acid SCHEMBL1703924 | 0.84 | KDM4E (0.68) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL2188470 | 0.82 | KDM4E (0.51) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL2188126 | 0.82 | ALDH1A1 (0.50) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL2186733 | 0.80 | KDM4E (0.48) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL1043606 | 0.80 | HPGD (0.49) | KDM4EPOLBGPR119MAPTTHRB | |
| SCHEMBL2186561 | 0.80 | NPSR1 (0.49) | KDM4EALDH1A1GPR119MAPTTHRB | |
| SCHEMBL14181451 | 0.79 | KDM4E (0.63) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL2186025 | 0.78 | KDM4E (0.46) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL21714539 | 0.77 | KDM4E (0.58) | KDM4EBRD4ALDH1A1POLBCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |