Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | SPR | P35270 | 7/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | ACACA | Q13085 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186733 | 0.88 | KDM4E (0.48) | ALDH1A1KDM4EBRD4POLBCREBBP | |
| SCHEMBL2188470 | 0.83 | KDM4E (0.51) | ALDH1A1KDM4EBRD4POLBCREBBP | |
| SCHEMBL2213735 | 0.82 | KDM4E (0.52) | ALDH1A1KDM4EBRD4POLBCREBBP | |
| SCHEMBL5774732 | 0.81 | KDM4E (0.43) | ALDH1A1KDM4EBRD4POLBCREBBP | |
| SCHEMBL5287621 | 0.81 | TACR1 (0.54) | ALDH1A1KDM4EBRD4POLBCREBBP | |
| SCHEMBL2186025 | 0.80 | KDM4E (0.46) | ALDH1A1KDM4EBRD4POLBCREBBP | |
| SCHEMBL5769877 | 0.80 | NPSR1 (0.51) | ALDH1A1KDM4EPOLBLMNAHTT | |
| SCHEMBL27698607 | 0.78 | KMT2A (0.46) | ALDH1A1KDM4EBRD4POLBCREBBP | |
| SCHEMBL27698609 | 0.78 | KMT2A (0.45) | ALDH1A1KDM4EBRD4POLBCREBBP | |
| SCHEMBL2187329 | 0.78 | SLC6A4 (0.45) | ALDH1A1KDM4EBRD4POLBCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |
| EP-1637529-A1 | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof | 4SC AG (DE) | 2006-03-22 | — | — | EP | disclosed |