Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 4/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2213757 | 1.00 | CACNA1G (0.36) | CACNA1GMAPK14MCHR1HTR2CSCN9A | |
| SCHEMBL2212137 | 0.93 | WDR5 (0.34) | CACNA1GMAPK14MCHR1HTR2CSCN9A | |
| SCHEMBL2212130 | 0.93 | WDR5 (0.34) | CACNA1GMAPK14MCHR1HTR2CSCN9A | |
| SCHEMBL2209797 | 0.84 | MAPK14 (0.36) | MAPK14HPGDKDM4EALDH1A1PTGER4 | |
| SCHEMBL2209792 | 0.84 | MAPK14 (0.36) | MAPK14HPGDKDM4EALDH1A1PTGER4 | |
| SCHEMBL2209907 | 0.82 | SCN9A (0.36) | MCHR1HTR2CSCN9AMAPTNAMPT | |
| SCHEMBL2209899 | 0.82 | SCN9A (0.36) | MCHR1HTR2CSCN9AMAPTNAMPT | |
| SCHEMBL2210663 | 0.82 | MAPK14 (0.34) | MAPK14HPGDALDH1A1 | |
| SCHEMBL2211289 | 0.82 | MAPK14 (0.34) | MAPK14HPGDALDH1A1 | |
| SCHEMBL1323886 | 0.81 | WDR5 (0.34) | CACNA1GMAPK14MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099769-B1 | 6-OXO.-1, 6-DIHYDROPYRIMIDIN-2-YLS IN THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2011-07-27 | — | — | EP | claimed |