Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.49 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.49 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018195 | 0.92 | HRH3 (0.70) | LTA4HPTGS2HRH3ATML3MBTL1 | |
| SCHEMBL82404 | 0.84 | HRH3 (0.59) | LTA4HHRH3KDM4EPSMB1PSMB5 | |
| SCHEMBL17198029 | 0.84 | LTA4H (0.59) | LTA4HHRH3KCNA5 | |
| SCHEMBL25305207 | 0.82 | LTA4H (0.60) | LTA4HPTGS2HRH3ATML3MBTL1 | |
| SCHEMBL229697 | 0.82 | LTA4H (0.90) | LTA4HPTGS2HRH3ATML3MBTL1 | |
| SCHEMBL14123709 | 0.80 | HRH3 (0.54) | LTA4HHRH3TSHRKDM4EPSMB1 | |
| SCHEMBL5116881 | 0.80 | LTA4H (0.87) | LTA4HPTGS2HRH3ATML3MBTL1 | |
| SCHEMBL227425 | 0.80 | LTA4H (0.87) | LTA4HPTGS2HRH3ATML3MBTL1 | |
| SCHEMBL227976 | 0.80 | LTA4H (0.87) | LTA4HPTGS2HRH3ATML3MBTL1 | |
| SCHEMBL23291256 | 0.80 | HRH3 (0.57) | LTA4HPTGS2HRH3PSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636290-B2 | BET inhibitors for modulating DUX4 expression in FSHD | SAINT LOUIS UNIVERSITY (US) | 2026-05-26 | — | — | US | disclosed |
| US-20220079951-A1 | BET INHIBITORS FOR MODULATING DUX4 EXPRESSION IN FSHD | SAINT LOUIS UNIVERSITY (US) | 2022-03-17 | — | — | US | disclosed |
| WO-2020132004-A1 | BET INHIBITORS FOR MODULATING DUX4 EXPRESSION IN FSHD | SAINT LOUIS UNIVERSITY (US) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220079951-A1 | BET INHIBITORS FOR MODULATING DUX4 EXPRESSION IN FSHD | BRDT, PHKB, BET1 | LTA4H 4417/4885PTGS2 4415/4885HRH3 3672/4885 |
| US-12636290-B2 | BET inhibitors for modulating DUX4 expression in FSHD | BRDT, BET1, PHKB | LTA4H 3972/4885PTGS2 4614/4885HRH3 1440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.