Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RXFP2 | Q8WXD0 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22138731 | 0.84 | ROCK2 (0.44) | HDAC3HDAC1HDAC2KDM4EALDH1A1 | |
| SCHEMBL19059708 | 0.81 | HDAC3 (0.47) | HDAC3HDAC1HDAC2ALDH1A1NPC1 | |
| SCHEMBL22853567 | 0.81 | HDAC3 (0.47) | HDAC3HDAC1HDAC2ALDH1A1NPC1 | |
| SCHEMBL21157257 | 0.80 | RAB9A (0.43) | HDAC3HDAC1HDAC2KDM4EALDH1A1 | |
| SCHEMBL20368588 | 0.77 | HDAC3 (0.44) | HDAC3HDAC1HDAC2KDM4EALDH1A1 | |
| SCHEMBL20368587 | 0.77 | HDAC3 (0.44) | HDAC3HDAC1HDAC2KDM4EALDH1A1 | |
| SCHEMBL21157773 | 0.77 | HDAC3 (0.44) | HDAC3HDAC1HDAC2KDM4EALDH1A1 | |
| SCHEMBL22018162 | 0.77 | HDAC3 (0.44) | HDAC3HDAC1HDAC2KDM4EALDH1A1 | |
| SCHEMBL22853729 | 0.77 | CDK2 (0.41) | HDAC3HDAC1HDAC2KDM4EALDH1A1 | |
| SCHEMBL22138688 | 0.76 | HDAC3 (0.36) | HDAC3HDAC1HDAC2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3670506-A1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | Incyte Holdings Corporation (US) | 2020-06-24 | — | — | EP | disclosed |