Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19059709 | 0.87 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2TSHRKMT2A | |
| SCHEMBL18399540 | 0.87 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2TSHRKMT2A | |
| SCHEMBL19059706 | 0.87 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2TSHRKMT2A | |
| SCHEMBL18399536 | 0.87 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2TSHRKMT2A | |
| SCHEMBL22018149 | 0.84 | KDM4E (0.50) | CAMKK1CAMKK2CYP2C9NPC1RAB9A | |
| SCHEMBL22138677 | 0.78 | MALT1 (0.54) | CYP2D6CYP2C9GLSRAB9ACCNE1 | |
| SCHEMBL15883606 | 0.76 | KDM4E (0.39) | PIK3CAMTORALDH1A1MEN1KMT2A | |
| SCHEMBL15883617 | 0.76 | PIM2 (0.42) | PIK3CAMTORALDH1A1MEN1KMT2A | |
| SCHEMBL22138631 | 0.71 | ADRA2A (0.37) | CYP2D6CYP2C9GLSALDH1A1HSD17B10 | |
| SCHEMBL24831669 | 0.71 | CCNE2 (0.36) | CYP2D6CYP2C9GLSALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4186897-A1 | PYRIDINECARBOXAMIDE COMPOUND USEFUL AS PIM KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2023-05-31 | — | — | EP | disclosed |
| EP-3670506-A1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | Incyte Holdings Corporation (US) | 2020-06-24 | — | — | EP | disclosed |